Next Generation Evolved and VHH- Modified AAV Vectors for Retinal Gene Transfer and Local Gene Delivery
Time: 11:00 am
day: Conference Day One
Details:
- Analyzing the transduction of multiplexed vectors for retinal gene transfer, following subretinal dosing at the single-cell level
- Exploring Revvity’s novel direct-targeted AAV vector platform, developed by inserting a VHH domain into the cap protein
- Optimizing production to generate yields of 1.4E14vg/l in suspension cells and enhanced in vitro and in vivo gene delivery
- Showcasing promising correlations between vector biodistribution and target receptor expression in vivo in an exploratory multiplexed NHP dosing study
