Discovering AAV Capsids for Ocular & CNS Gene Therapy by NAVIGATE Directed Evolution
Time: 11:00 am
day: Conference Day Two
Details:
- Exploring strategies for performing capsid directed evolution and considerations for on- vs off-target activity and toxicity
- Understanding how directed evolution of capsids in NHPs can facilitate targeting ocular tissues by non-invasive suprachoroidal space administration
- Emphasizing how capsids engineered in vitro permit crossing of the blood-brain barrier by targeting the transferrin receptor
